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graphics in this video we'll talk about
hydrochloric acid and how it is secreted
what regulates acid secretion in this topic
and from this we'll see how peptic also soft warm high stomach acid causes wounds in the stomach
and also why people have heart birds
finally we will see what drugs can be used to help with these traditions
will begin by looking at the gastric tassels
track started from the esophagus which comes down to
down from the mouth into next stunner the stomach that connects to the
duodenum
up this fall test arms this topic
produces 2.5 leaders have gastric juice per day
because of this the movement of the stomach the inside the stomach is very
City about one about a pH between one and two
you saw the a soft jheel sphincter
is a barrier between the acidic stomach and the esophagus to prevent the acid
from going
back towards the esophagus and the pyloric sphincter is the batter
between the acid a stunning and it would deter we would not want
acid from the stomach to go into the duodenum or the softest
otherwise in my clothes some uncomfortable conditions
acid that is secreted by this time it helps if you don't gestion
acid in the stomach is set for is secreted
as hypochlorous acid let's have a look high stomach acid causes wounds in the stomach
at the cells I'll just sum it and where
hydrochloric acid comes from and look at the overall picture of how
hydrochloric acid secretion is regulated
here we have the section of the stomach
it can be divided into three main
les is the mucosa on top
the submucosa and smooth muscle which is meant to be a lot bigger
and pictures dog ever and also we have a server software
book that's not true the submucosa contains have a daughter is to deliver
and return blood
to deliver this topic
have Chris where deferred stomach cells
all when we eat our nerves said signals that cause the parietal cells
just to secrete 104
acid which is necessary for seed I gesture here
we also have in terror home if it sells high stomach acid causes wounds in the stomach
around this area which secrete history history
in this case promotes hydrochloric acid secretion by the parietal cells
there are also G cells TG cells are
in to cart cells which secrete caster which
also promote hardcore secretion a 100 foot
acid secretion by the prior to Seoul's then we have another in two parts I'll
the diesels the cells secrete somatostatin
some at a Staten actually inhibits 100 clerk
acid secretion by inhibiting
are DG souls from releasing gaster
by inhibiting upright als cells from security high stomach acid causes wounds in the stomach
hydrochloric acid and by inhibiting terco sizzles disagree history
now
of course there are other things that regulate hydrochloric acid secretion
a real look into it more details suit probably the most important cells in the
gastrointestinal tract
are the cells on the tall and these are regular at the steel cells
or the mucous cells and they produce mucus
which helps protect the stomach from bacterial infection
as well as from the acidic environment obvious to me
another tough so worth mentioning this summer a chief cells that secrete pepcid
necessary for protein digestion okay
let's have a closer look at how hydrochloric acid is a creature
and how it is regulated by all these other
sells them surrounding it so here we have
some stomach cells we have the D cells the G cells and here we have the
parietal cells
the parietal cells secrete hydrochloric acid remember
and then we have the mucous cells here we have the in terror
from the stands I'll abbreviated he
see now the price will sell secretive hydrochloride
acid into the lumen of the stomach
which is situated here through a proton pump sort of thing
the product also secretes 104 acid by secreting
hydrogen-ion next eight in exchange for potassium low high stomach acid causes wounds in the stomach
and is a real secret this potassium iron again together with chloride are
dust for me hydrochloric acid in the stomach
simple hey CL is hydrochloric acid helps and food digestion
so what stimulates the process of secreting 104 asa
well as we mentioned Ecol secretes history
which by onto history to like receptors
on the prior to cells which will stimulate this whole process to secrete
hydrochloric acid
the G cells which are into crime cells will secrete
gastrin into the bloodstream from here gas turbine up to gas receptors on
Eccl which will stimulate histamine release which will then stimulate
hydrochloric acid secretion by Toronto cells
gas are also barred out to gas receptors on prior to social stability
hydrochloric acid secretion
up the Vegas dinner part the parasympathetic nerves
innervating the stomach area will secrete acetylcholine high stomach acid causes wounds in the stomach
which will bite on to muscarinic receptors on both parietal cells
and terror coveted cells which'll all promote
hydrochloric acid secretion
so all these were promoting hydrochloric acid secretion
the cells and mechanisms that inhibit hydrochloric acid secretion
include the hormone some back to Stockton which is secreted by the
DeSales
so some at a Stockton inhibits basically the hydrochloric acid secretion
also inflammatory mediators such as personal glad
e2 at prostaglandin I to drive from a record on it acid inhibits
are hydrochloric acid secretion
a record on it acid through the enzyme Cox considered the socket set the size
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